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The Benefits Of Probiotics: Study Compares The Effectiveness Of Two Different Strains

Do you know what probiotics can do for you?

hplictawa@gmail.com' by Editorial Team
May 7, 2022
in Research
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Lifestyle, Environmental, And Behavioral Management Of Inflammatory Bowel Disease
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Medically reviewed by Onikepe Adegbola, MD, PhD

Effectiveness of probiotics

Probiotics have been an important topic of discussion in the field of nutrition. They have shown many health benefits over the decades. These probiotics are the microorganisms that improve your gut microbiota. But there has been a debate on whether a healthy person should take a probiotic.

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Dr. John Damianos published his research in Supplement to the AEProbio Professional Discovery Review,  which mentioned the effect of probiotics on gut microbiota for a healthy individual. There were two types of studies performed using probiotics. In the first study, they administered a single-strain probiotic to healthy individuals for 30 days. The second study focused on the athletic performance of patients with a monitored diet.

First Study to Analyze Changes in Composition

The first trial consisted of 30 individuals. 15 healthy individuals received 1 * 109 Bifidobacterium infantis and 15 healthy individuals received placebo gelatin capsules. They collected the patient’s stool samples before the intervention, during the intervention, and 30 days after the intervention.

To determine whether the probiotic affected the microbiota, they performed 16S rRNA sequencing from these samples.

Effects of Probiotics on the Gut Microbiota Of Healthy Individual 

Probiotics do not alter the microbiome composition. Researchers observed that probiotics may not affect the composition and diversity of a healthy gut microbiome functionally. According to this study, probiotics do not alter the composition of the microbiome in healthy people.

They concluded that probiotics may have benefited only in states of dysbiosis, where the microbiota is disrupted, and not in healthy individuals with healthy microbiota.

However, this study comes with several limitations. Since the sample size was very small, the results may not be generalizable. Additionally, probiotics may not have to affect microbiome composition for them to exert their beneficial effects. Most probiotics do not colonize the gut, so the effects of probiotic supplementation cease once the supplementation is stopped.

Second Study To Analyze The Functional Effect

Scientists wanted to observe the effect of Bacillus coagulans Unique IS-2 supplementation on muscle strength in resistance-trained males. They combined the administration of probiotics with whey protein.

This study assessed the effects of probiotic supplementation on athletic performance in healthy individuals. The study involved 35 healthy males who took 2 billion CFU Bacillus coagulans Unique IS-2 mixed with 20 g of whey protein every day for 60 days. The control group consisted of 35 healthy males (age 18–25) who received 20 g of whey protein mixed with lactose. All the participants underwent specific resistance exercises with a full-body workout.

Effects of Probiotics on Athletic Performance 

Despite its small size, this study was well designed and used an appropriate placebo. They found that in spite of intensive dietary counseling and structured exercise, the probiotic group performed better than the control group, possibly due to the increased protein absorption.

Unlike the first study, this one focused on functional outcomes instead of microbiome composition. Hence, they concluded that probiotics may be beneficial to healthy individuals since they improve athletic performance. But it is still unknown whether the microbiota was altered by B. coagulans or not. However, the benefits can be seen in the results.

Key Takeaway

To better understand how this probiotic works, larger trials are needed to evaluate the microbiome response. Future trials should recruit a more diverse cohort to determine the external validity of this study.

Treatments for some gut microbiota diseases are still being investigated. Probiotics might unveil new treatments in the future.

We need larger, better-powered trials involving specific single- and multi-strain probiotics to clarify this issue.

Reference:

Dr. J. Damianos (2022). Supplementation of a single species probiotic does not affect the diversity and composition of the healthy adult gastrointestinal microbiome. Supplement to the AEProbio Professional Discovery Review, 4(1), 1-3

Tags: gut bacteriagut microbiotaprobiotics
hplictawa@gmail.com'

Editorial Team

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A research paper was published in the Brazilian Journal of Biology, titled "Using Bifidobacterium and Propionibacterium Strains in Probiotic Consortia to Normalize the Gastrointestinal Tract." Based on expert opinions in the study, the microorganisms Bifidobacterium and Propionibacterium genera qualities can be preserved and encapsulated. This research backs up expert suggestions with clinical evidence, proving that the experts were correct. The gut microflora is responsible for regulating the body's activities and maintaining its health. Diabetes, obesity, inflammation, atherosclerosis, and other chronic diseases are due to dysbiosis. In the 2024 recommendations, experts recommended probiotics for living microorganisms that benefit the microflora and improve the health of the host organism helping prevent these diseases. Lactic acid bacteria from the Bifidobacterium and Propionibacterium genera are the frequent probiotics recommended. Bifidobacterium adolescentis-1909, Bifidobacterium longum infantis-1912, Propionibacterium jensenii B-6085, Propionibacterium freudenreichii -11921, Propionibacterium thoenii -6082, and Propionibacterium acidipropionici-5723 were examined for their probiotic characteristics in the study. This study was conducted in the Laboratory for Bio testing Natural Nutraceuticals at Kemerovo State University (Russia). The study used collection strains of the lactic acid bacteria Bifidobacterium adolescentis АС-1909, Bifidobacterium longum infantis АС-1912, Propionibacterium jensenii В-6085, Propionibacterium freudenreichiiВ-11921, Propionibacterium thoenii В-6082, and Propionibacterium acidipropionici В-5723. Lactic acid cultures were tested for antibacterial activity against the test cultures Salmonella enterica ATCC 14028, Staphylococcus aureusATCC 25923, Pseudomonas aeruginosa B6643, Proteus Vulgaris ATCC 63, and Listeria monocytogenes ATCC 7644. Additionally, the antibiotic resistance of lactic acid cultures was tested using the disk diffusion method. Bifidobacterium adolescentis-1909, Propionibacterium jensenii B-6085, and Propionibacterium thoenii 6082 showed moderate antibacterial activities against all test cultures. According to research, some Propionibacterium and Bifidobacterium strains, or their consortia, could be employed as probiotic cultures in dietary supplements or functional foods to prevent various chronic diseases like IBS. Why is this study important for patients with IBS Symptoms Although IBS is bothersome and inconvenient, it does not increase the chance of developing other health problems. However, the success of the treatment depends on what grade of IBS it is and how it is addressed. Bifidobacterium bacteria are particularly significant compared with other gut microbiota in probiotic cultures. Probiotics have a favorable effect in four ways. First, they produce antimicrobial compounds. Second, they are hostile to pathogenic and opportunistic strains. They also adhere to epithelial cells (cells of intestinal walls), posing a competitive threat to disease-causing bacteria. Finally, they inhibit the production of metabolites by pathogenic bacteria and cancer cells. What is the Key Takeaway from this Study Large doses of probiotics that contain these bacteria in dietary supplements or functional fermented milk products can stimulate their proliferation in the large intestine. The development of functional foods containing probiotics, particularly Bifidobacterium strains, is driven by the increased demand for health-beneficial foods. However, Propionibacterium 'dairy' strains have recently gained popularity. As a result, probiotic consortia of these species can be established to normalize the gastrointestinal microbiota's function. To preserve their quality, these microorganisms can be encapsulated (immobilized). All the strains can be employed to form various dietary supplements or functional product consortia.
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A research paper was published in the Brazilian Journal of Biology, titled "Using Bifidobacterium and Propionibacterium Strains in Probiotic Consortia to Normalize the Gastrointestinal Tract." Based on expert opinions in the study, the microorganisms Bifidobacterium and Propionibacterium genera qualities can be preserved and encapsulated. This research backs up expert suggestions with clinical evidence, proving that the experts were correct. The gut microflora is responsible for regulating the body's activities and maintaining its health. Diabetes, obesity, inflammation, atherosclerosis, and other chronic diseases are due to dysbiosis. In the 2024 recommendations, experts recommended probiotics for living microorganisms that benefit the microflora and improve the health of the host organism helping prevent these diseases. Lactic acid bacteria from the Bifidobacterium and Propionibacterium genera are the frequent probiotics recommended. Bifidobacterium adolescentis-1909, Bifidobacterium longum infantis-1912, Propionibacterium jensenii B-6085, Propionibacterium freudenreichii -11921, Propionibacterium thoenii -6082, and Propionibacterium acidipropionici-5723 were examined for their probiotic characteristics in the study. This study was conducted in the Laboratory for Bio testing Natural Nutraceuticals at Kemerovo State University (Russia). The study used collection strains of the lactic acid bacteria Bifidobacterium adolescentis АС-1909, Bifidobacterium longum infantis АС-1912, Propionibacterium jensenii В-6085, Propionibacterium freudenreichiiВ-11921, Propionibacterium thoenii В-6082, and Propionibacterium acidipropionici В-5723. Lactic acid cultures were tested for antibacterial activity against the test cultures Salmonella enterica ATCC 14028, Staphylococcus aureusATCC 25923, Pseudomonas aeruginosa B6643, Proteus Vulgaris ATCC 63, and Listeria monocytogenes ATCC 7644. Additionally, the antibiotic resistance of lactic acid cultures was tested using the disk diffusion method. Bifidobacterium adolescentis-1909, Propionibacterium jensenii B-6085, and Propionibacterium thoenii 6082 showed moderate antibacterial activities against all test cultures. According to research, some Propionibacterium and Bifidobacterium strains, or their consortia, could be employed as probiotic cultures in dietary supplements or functional foods to prevent various chronic diseases like IBS. Why is this study important for patients with IBS Symptoms Although IBS is bothersome and inconvenient, it does not increase the chance of developing other health problems. However, the success of the treatment depends on what grade of IBS it is and how it is addressed. Bifidobacterium bacteria are particularly significant compared with other gut microbiota in probiotic cultures. Probiotics have a favorable effect in four ways. First, they produce antimicrobial compounds. Second, they are hostile to pathogenic and opportunistic strains. They also adhere to epithelial cells (cells of intestinal walls), posing a competitive threat to disease-causing bacteria. Finally, they inhibit the production of metabolites by pathogenic bacteria and cancer cells. What is the Key Takeaway from this Study Large doses of probiotics that contain these bacteria in dietary supplements or functional fermented milk products can stimulate their proliferation in the large intestine. The development of functional foods containing probiotics, particularly Bifidobacterium strains, is driven by the increased demand for health-beneficial foods. However, Propionibacterium 'dairy' strains have recently gained popularity. As a result, probiotic consortia of these species can be established to normalize the gastrointestinal microbiota's function. To preserve their quality, these microorganisms can be encapsulated (immobilized). All the strains can be employed to form various dietary supplements or functional product consortia.
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Medically reviewed by Onikepe Adegbola, MD, PhD  Image from Unsplash A research paper was published in the...

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Dope Entrepreneurs is the hub for all dope gut health related content. We are a groundbreaking news publication dedicated to gut health. We cover gut health research, entrepreneurship, startups and the latest trends in gut health. We serve a growing segment of patients, entrepreneurs and investors who want to learn more about gut health, the disruption and market potential in this field, and how they can benefit from the latest advances in gut health. Dope entrepreneurs is led by Onikepe Adegbola, MD PhD DipIBLM, physician, scientist, and gut health entrepreneur.

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